Ghilardi, Nico: search on Z-Library

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1

Discovery of GDC-0853, a Potent, Selective, and Non-Covalent Bruton’s Tyrosine Kinase Inhibitor in Early Clinical Development

Crawford, James J., Johnson, Adam R., Misner, Dinah L., Belmont, Lisa D., Castanedo, Georgette M., Choy, Regina, Coraggio, Melis, Dong, Liming, Eigenbrot, Charles, Erickson, Rebecca, Ghilardi, Nico, H

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.72 MB

english, 2018

2

Hereditary thrombocythaemia in a Japanese family is caused by a novel point mutation in the thrombopoietin gene

Nico Ghilardi, Adrian Wiestner, Masahiro Kikuchi, Akimichi Ohsaka, Radek C. Skoda

Journal:

British Journal of Haematology

Year:

1999

Language:

english

File:

PDF, 258 KB

english, 1999

3

The biology and therapeutic potential of interleukin 27

Marcel Batten, Nico Ghilardi

Journal:

Journal of Molecular Medicine

Year:

2007

Language:

english

File:

PDF, 437 KB

english, 2007

4

10.1038/35038103

de Sauvage, Frederic J., Chen, Qi, Ghilardi, Nico, Wang, Hua, Baker, Thad, Xie, Ming-Hong, Gurney, Austin, Grewal, Iqbal S.

Journal:

Year:

2000

Language:

english

File:

PDF, 165 KB

english, 2000

5

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17–producing T cells

Batten, Marcel, Li, Ji, Yi, Sothy, Kljavin, Noelyn M, Danilenko, Dimitry M, Lucas, Sophie, Lee, James, de Sauvage, Frederic J, Ghilardi, Nico

Journal:

Nature Immunology

Year:

2006

Language:

english

File:

PDF, 655 KB

english, 2006

6

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

Zheng, Yan, Valdez, Patricia A, Danilenko, Dimitry M, Hu, Yan, Sa, Susan M, Gong, Qian, Abbas, Alexander R, Modrusan, Zora, Ghilardi, Nico, de Sauvage, Frederic J

Journal:

Nature Medicine

Year:

2008

Language:

english

File:

PDF, 521 KB

english, 2008

7

Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors

Kulagowski, Janusz J., Blair, Wade, Bull, Richard J., Chang, Christine, Deshmukh, Gauri, Dyke, Hazel J., Eigenbrot, Charles, Ghilardi, Nico, Gibbons, Paul, Harrison, Trevor K., Hewitt, Peter R., Liima

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 2.23 MB

english, 2012

8

Regulation of myeloid progenitor cell proliferation/survival by IL-31 receptor and IL-31

Hal E. Broxmeyer, Ji Li, Giao Hangoc, Scott Cooper, Wen Tao, Charlie Mantel, Barbara Graham-Evans, Nico Ghilardi, Frederic J. de Sauvage

Journal:

Experimental Hematology

Year:

2007

Language:

english

File:

PDF, 488 KB

english, 2007

9

CRIg: A Macrophage Complement Receptor Required for Phagocytosis of Circulating Pathogens

Karim Y. Helmy, Kenneth J. Katschke Jr., Nick N. Gorgani, Noelyn M. Kljavin, J. Michael Elliott, Lauri Diehl, Suzie J. Scales, Nico Ghilardi, Menno van Lookeren Campagne

Journal:

Year:

2006

Language:

english

File:

PDF, 1.05 MB

english, 2006

10

PS1-20 IL-27 promotes T-cell dependent colitis through restriction of regulatory T-cell differentiation

Jennifer H. Cox, Noelyn M. Kljavin, Nandhini Ramamoorthi, Lauri Diehl, Nico Ghilardi

Journal:

Year:

2010

Language:

english

File:

PDF, 42 KB

english, 2010

11

SS1-7 IL-27 supports germinal center function through combined effects on T follicular helper cells and B cells

Marcel Batten, Nandhini Ramamoorthi, Noelyn Kljavin, Nico Ghilardi

Journal:

Year:

2010

Language:

english

File:

PDF, 35 KB

english, 2010

12

CS02-2. Dichotomous consequences of IL-23 signaling in chemically induced colitis in mice

Jennifer H Cox, Noelyn M. Kljavin, Lauri Diehl, Wenjun Ouyang, Nico Ghilardi

Journal:

Year:

2011

Language:

english

File:

PDF, 135 KB

english, 2011

13

Bystanders Not So Innocent after All

Marcel Batten, Nico Ghilardi

Journal:

Year:

2012

Language:

english

File:

PDF, 121 KB

english, 2012

14

Targeting the development and effector functions of TH17 cells

Nico Ghilardi, Wenjun Ouyang

Journal:

Seminars in Immunology

Year:

2007

Language:

english

File:

PDF, 475 KB

english, 2007

15

Hedgehog Signaling Is Dispensable for Adult Murine Hematopoietic Stem Cell Function and Hematopoiesis

Inga Hofmann, Elizabeth H. Stover, Dana E. Cullen, Junhao Mao, Kelly J. Morgan, Benjamin H. Lee, Michael G. Kharas, Peter G. Miller, Melanie G. Cornejo, Rachel Okabe, Scott A. Armstrong, Nico Ghilardi

Journal:

Year:

2009

Language:

english

File:

PDF, 861 KB

english, 2009

16

Endogenous interleukin (IL)-23 protects against acinar injury in lipopolysaccharide (LPS)-mediated mouse severe acute pancreatitis

Gregory M. Boucher, Albert E. Stanek, Sidharth Sharma, Cathy M. Mueller, Gainosuke Sugiyama, Thomas K. Weber, Nico Ghilardi, Wenjun Ouyang, Antonio E. Alfonso, Chongmin Huan

Journal:

Journal of the American College of Surgeons

Year:

2012

Language:

english

File:

PDF, 94 KB

english, 2012

17

Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors

Liang, Jun, van Abbema, Anne, Balazs, Mercedesz, Barrett, Kathy, Berezhkovsky, Leo, Blair, Wade, Chang, Christine, Delarosa, Donnie, DeVoss, Jason, Driscoll, Jim, Eigenbrot, Charles, Ghilardi, Nico, G

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 2.57 MB

english, 2013

18

Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1

Hurley, Christopher A., Blair, Wade S., Bull, Richard J., Chang, Christine, Crackett, Peter H., Deshmukh, Gauri, Dyke, Hazel J., Fong, Rina, Ghilardi, Nico, Gibbons, Paul, Hewitt, Peter R., Johnson, A

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.23 MB

english, 2013

19

Lead identification of novel and selective TYK2 inhibitors

Liang, Jun, Tsui, Vickie, Van Abbema, Anne, Bao, Liang, Barrett, Kathy, Beresini, Maureen, Berezhkovskiy, Leo, Blair, Wade S., Chang, Christine, Driscoll, James, Eigenbrot, Charles, Ghilardi, Nico, Gi

Journal:

European Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 2.05 MB

english, 2013

20

2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors

Siu, Michael, Pastor, Richard, Liu, Wendy, Barrett, Kathy, Berry, Megan, Blair, Wade S., Chang, Christine, Chen, Jacob Z., Eigenbrot, Charles, Ghilardi, Nico, Gibbons, Paul, He, Haiying, Hurley, Chris

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 3.25 MB

english, 2013

21

238

Shih, Vincent Feng-Sheng, Cox, Jennifer, Kljavin, Noelyn, Rardin, Hart, Reichelt, Michael, Rangell, Linda, Diehl, Lauri, Ouyang, Wenjun, Ghilardi, Nico

Journal:

Year:

2013

Language:

english

File:

PDF, 42 KB

english, 2013

22

Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2

Labadie, Sharada, Dragovich, Peter S., Barrett, Kathy, Blair, Wade S., Bergeron, Philippe, Chang, Christine, Deshmukh, Gauri, Eigenbrot, Charles, Ghilardi, Nico, Gibbons, Paul, Hurley, Christopher A.,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 4.94 MB

english, 2012

23

Defective STAT Signaling by the Leptin Receptor in Diabetic Mice

Nico Ghilardi, Sandra Ziegler, Adrian Wiestner, Ruedi Stoffel, Markus H. Heim and Radek C. Skoda

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 1.12 MB

english, 1996

24

Permissive Role of Thrombopoietin and Granulocyte Colony-Stimulating Factor Receptors in Hematopoietic Cell Fate Decisions in vivo

Ruedi Stoffel, Sandra Ziegler, Nico Ghilardi, Birgit Ledermann, Frederic J. De Sauvage and Radek C. Skoda

Journal:

Proceedings of the National Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 1.55 MB

english, 1999

25

The Leptin Receptor Activates Janus Kinase 2 and Signals for Proliferation in a Factor-Dependent Cell Line

Ghilardi, Nico, Skoda, Radek C.

Journal:

Molecular Endocrinology

Year:

1997

Language:

english

File:

PDF, 1.17 MB

english, 1997

26

Nonselective inhibition of the epigenetic transcriptional regulator BET induces marked lymphoid and hematopoietic toxicity in mice

Lee, Dong U., Katavolos, Paula, Palanisamy, Gopinath, Katewa, Arna, Sioson, Charly, Corpuz, Janice, Pang, Jodie, DeMent, Kevin, Choo, Edna, Ghilardi, Nico, Diaz, Dolores, Danilenko, Dimitry M.

Journal:

Toxicology and Applied Pharmacology

Year:

2016

Language:

english

File:

PDF, 1.20 MB

english, 2016

27

T Cell–Derived IL-10 Impairs Host Resistance to Mycobacterium tuberculosis Infection

Moreira-Teixeira, Lúcia, Redford, Paul S., Stavropoulos, Evangelos, Ghilardi, Nico, Maynard, Craig L., Weaver, Casey T., Freitas do Rosário, Ana Paula, Wu, Xuemei, Langhorne, Jean, O’Garra, Anne

Journal:

The Journal of Immunology

Year:

2017

Language:

english

File:

PDF, 1.65 MB

english, 2017

28

Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus

Håkansson, Marie-Louise, Brown, Hilary, Ghilardi, Nico, Skoda, Radek C., Meister, Björn

Journal:

Journal of Neuroscience

Year:

1998

Language:

english

File:

PDF, 1.66 MB

english, 1998

29

Functional Studies on the IBD Susceptibility Gene IL23R Implicate Reduced Receptor Function in the Protective Genetic Variant R381Q

Pidasheva, Svetlana, Trifari, Sara, Phillips, Anne, Hackney, Jason A., Ma, Yan, Smith, Ashley, Sohn, Sue J., Spits, Hergen, Little, Randall D., Behrens, Timothy W., Honigberg, Lee, Ghilardi, Nico, Cla

Journal:

Year:

2011

Language:

english

File:

PDF, 796 KB

english, 2011

30

Thrombopoietin Production Is Inhibited by a Translational Mechanism

Ghilardi, Nico, Wiestner, Adrian, Skoda, Radek C.

Journal:

Year:

1998

Language:

english

File:

PDF, 429 KB

english, 1998

31

A Single-Base Deletion in the Thrombopoietin (TPO) Gene Causes Familial Essential Thrombocythemia Through a Mechanism of More Efficient Translation of TPO mRNA

Ghilardi, Nico, Skoda, Radek C.

Journal:

Year:

1999

File:

PDF, 117 KB

1999

32

30 Years of Biotherapeutics DevelopmentâWhat Have We Learned?

Ghilardi, Nico, Pappu, Rajita, Arron, Joseph R., Chan, Andrew C.

Journal:

Annual Review of Immunology

Year:

2020

File:

PDF, 536 KB

2020

33

The role of IL-22 in intestinal health and disease

Keir, Mary E., Yi, Tangsheng, Lu, Timothy T., Ghilardi, Nico

Journal:

Journal of Experimental Medicine

Year:

2020

File:

PDF, 1.14 MB

2020